| Champions League Top Scorers 1955-2025 - Shakhtar Donetsk |
| 1 | Luiz Adriano | 20 | 2010 | 2014 |
| 2 | Alex Teixeira | 11 | 2012 | 2015 |
| 3 | Jadson | 9 | 2006 | 2011 |
| 4 | Willian | 7 | 2008 | 2012 |
| 5 | Douglas Costa | 6 | 2010 | 2014 |
| 6 | Danylo Silkan | 5 | 2023 | 2024 |
| 7 | Junior Moraes | 5 | 2018 | 2019 |
| 8 | Eduardo | 5 | 2010 | 2015 |
| 9 | Alexander Zubkov | 4 | 2022 | 2024 |
| 10 | Manor Solomon | 4 | 2019 | 2020 |